Abstract:Abstract: OBJECTIVE To investigate the behavior of adolescents with depressive disorder accompanied by non-suicidal self-in⁃ jury (NSSI), and to explore the influence of music therapy on NSSI behavior of adolescents with depressive disorder. METHODS A to⁃ tal of 63 adolescent depressive disorder patients with NSSI behavior admitted to Zhongshan Third People’s Hospital from March 2022 to March 2023 were randomly divided into control group (32 cases) and study group (31 cases). The control group received sim⁃ ple drug therapy and routine nursing, and the study group received 4 weeks of music therapy. NSSI behavior was assessed using the Ottawa Self-injury Scale (OSI) before enrollment; compare the scores of the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD-17) at 1, 2, and 4 weeks before treatment; and compare the incidence of NSSI behavior at 1, 2, and 4 weeks of treat⁃ ment. RESULTS The most common form of SCI in both groups was knife cut (72.1%) and the most common lesion was hand (47.6%). The largest number of patients had done it one way (52.5%), and 52.4% had done it at least one time in the past 1 month. At 1, 2 and 4 weeks of treatment, HAMA and HAMD-17 scores decreased compared with before treatment, statistically significant (P＜ 0.05), and the study group was significantly lower than the control group. The incidence of NSSI behavior was significantly reduced in both patients after treatment groups, especially at 2 and 4 weeks of treatment, and the incidence of NSSI behavior in the study group was significantly lower than that in the control group. CONCLUSION Music therapy can effectively relieve anxiety and depres⁃ sion in adolescents with depressive disorder, reduce the incidence of NSSI behavior, and improve clinical efficacy.