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中文摘要: 摘 要：目的：探讨老年性痴呆患者精神行为症状的影响因素及认知行为疗法干预的效果。方法：选取 2020年 6月—
2022 年 6 月上海市静安区精神卫生中心收治的 86 例老年性痴呆患者作为研究对象，将患者随机分为认知行为干预组 （n=
43） 及常规干预组 （n=43），分别进行认知行为疗法干预和常规干预，对比干预前后两组患者精神行为症状调查表
（NPI-Q）、简易智能精神状态量表 （MMSE）、Barthel指数 （BI） 及健康状态调查表 （GQOL-74） 评分。结果：发生精神行为
症状的患者有 80例，发病率为 93.02% （80/86），不同年龄、病程、睡眠障碍、婚姻状况、生活自理情况患者 NPI-Q评分比
较，差异有统计学意义 （P＜0.05）。logistic回归分析结果显示，年龄、病程、婚姻状况、睡眠障碍、生活自理情况是精神行
为症状的影响因素 （P＜0.05）。干预后认知行为干预组MMSE评分为 （24.61±2.19） 分、BI评分为 （70.19±4.22） 分，明显高
于常规干预组的 （22.18±2.46） 分、（66.28±3.29） 分；干预后认知行为干预组NPI-Q评分为 （13.51±1.61） 分，低于常规干预
组的 （14.70±1.22） 分，差异均有统计学意义 （P值均＜0.05）。干预后认知行为干预组心理功能评分为 （27.51±6.78） 分、社
会功能评分为 （18.86±3.64） 分、躯体功能评分为 （15.74±1.83） 分、物质生活评分为 （20.36±2.71） 分，均高于常规干预组
的 （23.53±5.59） 分、（15.73±2.26） 分、（13.39±1.59） 分、（18.57±2.58） 分，差异均有统计学意义 （P 值均＜0.05）。结论：
老年性痴呆患者精神行为症状的发生率较高，其发生与年龄、病程、婚姻状况、睡眠障碍、生活自理情况等因素有关。认知
行为疗法干预能明显改善老年性痴呆患者的精神行为症状和认知功能，改善患者的自理能力及生活质量。
Abstract:Abstract: OBJECTIVE To explore the influencing factors of mental behavioral symptoms in patients with Alzheimer’s disease
and the value of cognitive behavioral therapy intervention. METHODS A total of 86 Alzheimer patients from June 2020 to June 2022
were selected and their general data were collected. In a single blind randomized controlled clinical trial, all Alzheimer patients
were divided into cognitive behavioral therapy group (n=43) and conventional therapy group (n=43). Cognitive behavioral therapy in⁃
tervention and conventional therapy were performed, respectively. The scores of nPI-Q, Mini Mental State Scale (MMSE), Barthel In⁃
dex (BI), and Health Status Questionnaire (GQOL-74) before and after the intervention were compared. RESULTS Taking 86 Al⁃
zheimer’ s disease patients as the research object, 80 patients with mental behavioral symptoms were found. Comparing nPI-Q
scores of different clinical data, it was found that there were statistically significant differences in age, course of disease, marital sta⁃
tus, sleep disorders, and self care status (P＜0.05). When it was included in the logistic regression model, age, course of disease,
marital status, sleep disorders, and self care were the influencing factors for the occurrence of mental behavioral symptoms (P＜
0.05); after intervention， the scores of MMSE and BI in cognitive behavioral therapy group were significantly higher than those in
conventional therapy group and before intervention， while the nPI-Q scores were lower than those in conventional therapy group
and before intervention (P＜0.05); after intervention， the psychological function， social function， physical function， and materi⁃
al life in the cognitive behavioral treatment group were significantly higher than those before intervention and higher than those in
the conventional treatment group after intervention (P＜0.05). CONCLUSION The incidence of mental behavioral symptoms in Al⁃
zheimer’s disease patients is high， and its occurrence is related to factors such as age， course of disease， marital status， sleep
disorders， and self care status. After cognitive behavioral therapy intervention， it can significantly improve the mental behavioral
symptoms and cognitive function of Alzheimer’s disease patients， and improve their self care ability and quality of life.
keywords: Keywords: Alzheimer’s disease psychobehavioral symptoms cognitive behavioral therapy influence factor
文章编号：3202110021 中图分类号：R749.16 文献标志码：
基金项目:
| 作者 | 单位 |
| 刘太琴，田金昌 |
| Author Name | Affiliation |
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