Abstract:OBJECTIVE To observe the influence of Yueju pill with ursodeoxycholic acid on effects and plasma motilin (MTL) and vasoactive intestinal peptide (VIP) of patients with liver cirrhosis and stomach-type bile reflux gastritis. METHODS 86 cases of patients with bile reflux gastritis treated in our hospital from January 2015 to July 2016 were selected as the study objects, and were divided into control group and observation group, 43 cases in each group. The control group were given ursodeoxycholic acid treatment, and the observation group were added Yueju pill treatment on the basis of the control group, with continuous treatment for 4 weeks. TCM symptoms and Gastroscopy changes were observed before and after treatment in the two groups, plasma MTL and VIP levels were examined before and after treatment, and the incidence of adverse reactions was statistically analyzed. RESULTS After treatment, TCM syndromes scores were significantly lower than those before treatment in the two groups, which of the observation group were significantly lower than those in the control group (P < 0.05). Plasma MTL level increased in the two groups, and that in the observation group was significantly higher than that in the control group (P < 0.05). Plasma VIP level decreased in the two groups, and that in the observation group was significantly lower than that in the control group (P < 0.05). Total effective rate of the observation group was 93.02%, significantly higher than that of 74.42% of the control group (P< 0.05). The adverse reaction rates of the observation group and the control group was 6.98% and 4.65%, respectively,with no significant difference between the two groups (P > 0.05). CONCLUSION Yueju pill with ursodeoxycholic acid in treatment of liver cirrhosis and stomach-type bile reflux gastritis, it can improve clinical symptoms of patients, treatment effect, and plasma MTL and VIP levels. It can provide clinical guidance for treatment.