Abstract:OBJECTIVE To analyze the value of regular hepatectomy combined with choledochoscope in the treatment of intrahepatic chalangiocarcinoma. METHODS Totally 94 patients with complicated intrahepatic chalangiocarcinoma were randomly divided into observation group (n=47) and control group (n=47). The patients in observation group were treated with regular hepatectomy combined with choledochoscope, while those in control group with multiple hepalobectomy combined with choledochoscope. The therapeutic effect and condition of hepatic lobes were observed in two groups, the changes of liver function indexes were compared before and after surgery, and the incidence of postoperative complications were recorded. RESULTS The excellent rate of 95.74% in observation group was markedly higher than 78.72% in control group (P＜0.05). No significant difference was shown between two groups regarding the condition of hepatic lobes (P＞0.05). Compared with 1 d before surgery, the levels of alanine aminotransferase (ALT), aspartic transaminase (AST) and total bilirubin (TBIL) went down dramatically (P＜0.01), whereas those of albumin (ALB) and prothrombin time (PT) had no obvious change 7 d after surgery in both groups (P＞0.05). The incidence of postoperative complications and residual rate of stones in observation group were 14.89% and 6.38%, significantly lower than 33.33% and 21.28% in control group (P＜0.05). CONCLUSION For intrahepatic chalangiocarcinoma, regular hepatectomy combined with choledochoscope can effectively reduce postoperative complications and occurrence of stone residue, with significant efficacy, so it deserves to be popularized and applied in clinic.