Abstract:OBJECTIVE To investigate the incidence trend and rank order of cancer during 2001-2016 in Baoan district of Shenzhen，so as to evaluate the development of relevant policies and strategies. METHODS Data was obtained from Shenzhen Cancer Register and descriptive method was performed to assess the trend of incidence and rank order of cancer from 2001-2016. RESULTS The crude incidences of cancer were 25.67, 29.61, 47.31 and 113.22/105 and 0-74 cumulative rates were 12.36, 10.93, 17.37 and 38.96% in 2001, 2006, 2011 and 2016, respectively. And the corresponding age-standardized rates by 2000 Chinese population (ASRC) were 231.28, 177.27, 229.54 and 458.10/105. The average ages of diagnosis were 53.4, 50.5, 49.7and 49.8 years old. During the past fifteen years, the crude and age-standardized rates were higher in males than in females, but the increased and younger trends were more obvious in females than in males. The type of cancers in the top 10 kept stable in the past 15 years with constituent ratio decreasing from 82.2% in 2001 to 70% in 2016, expect that esophageal and neurological tumors replaced by thyroid cancer and carcinoma in situ. CONCLUSIONS The crude incidence rates of cancer were low but the ASRCs high, with increasing and younger trend, especially for females. Leukemia and nasopharyngeal cancer were in the top 10 and were endemic in Baoan district. Some effective measures were making to halt the fast increasing trend of thyroid cancer.