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中文摘要: 目的 观察14例急性缺血性脑卒中患者溶栓前后血液中Apelin水平的变化。方法 选取14例行急诊溶栓治疗的急性缺血性脑卒中患者作为溶栓组，选取10例年龄、性别、血脂、血糖、肝酶和血肌酐等临床特性相匹配，但未能行溶栓治疗的急性缺血性脑卒中患者作为对照组，分别测量溶栓组患者溶栓前、溶栓后12 h、溶栓后24 h的Apelin水平，并与对照组治疗前后的Apelin水平进行比较。结果 两组患者在治疗前的Apelin水平无显著差异(P＞0.05)。溶栓组患者在溶栓后体内Apelin水平比溶栓前显著下降（P＜0.05）。结论 急性缺血性脑卒中患者溶栓后24 h内再灌注损伤引起Apelin水平显著下降。
Abstract:OBJECTIVE To observe the changes of serum Apelin levels in 14 patients with acute ischemic stroke before and after thrombolysis. METHODS A total of 24 patients with acute ischemic stroke were enrolled in this study, including 14 patients treated with thrombolysis, and 10 patients with conservative treatment. The related clinical characteristics with stroke were tested, including the fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), creatinine, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), glutamic-oxalacetic transaminase (AST), and serum Apelin level before and after therapy.RESULTS There was no significant difference in the level of Apelin between the two groups before treatment (P＞0.05). The level of Apelin in thrombolysis group was significantly decreased after thrombolysis (P＜0.05). CONCLUSION After thrombolytic therapy, the serum Apelin level of acute ischemic stroke patients decreased significantly within 24 hours after reperfusion.
keywords: acute ischemic stroke thrombolysis Apelin
文章编号：3201806036 中图分类号：R743 文献标志码：
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