Abstract:OBJECTIVE To investigate the clinical effect of sequential therapy of erythromycin and azithromycin in children with mycoplasma pneumonia (MPP). METHODS 94 cases of MPP children received in our hospital in January 2017 ~2018 and January were included in the study. Based on the digital table method, the experimental group and the routine group were randomly divided into the experimental group and the routine group, with 47 cases in each group. The 2 groups were given the basic symptomatic treatment, the routine group was treated with erythromycin and the experimental group was treated with erythromycin and Azithromycin Sequential therapy. After the completion of the treatment, the comparative analysis was made after the treatment completed, the comparative analysis of the clinical treatment was made. The clinical effect of bed. RESULTS The total effective rate was 95.74% in the experimental group and 82.98% in the routine group (P < 0.05). The cough disappearance time, the time of fever, the disappearance time and the time of hospitalization were significantly shorter than those in the routine group (P < 0.05), and the adverse reaction rate of the test group was lower than that of the conventional group (P < 0.05). CONCLUSION The sequential treatment of erythromycin and azithromycin in children with MPP is effective, and it can effectively improve the symptoms of the children, and it has high safety. The whole is better than the single use of erythromycin. It has important clinical value.