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中文摘要: 目的 分析慢性阻塞性肺疾病（COPD）患者合并抑郁情况及其相关因素，并探讨血清细胞因子白介素lβ(IL-1β)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)与COPD患者抑郁情绪的相关性。方法 采用问卷调查法及抑郁自评量表(SDS)分组，用酶联免疫吸附法(ELISA)测定健康对照者及COPD患者血清IL-1β、IL-6和TNF-α水平。结果 COPD患者抑郁的发生率明显高于健康对照组；COPD对照组IL-1β、IL-6和TNF-α水平显著高于健康对照组，但较COPD伴抑郁情绪组明显偏低；不同抑郁程度的COPD患者，其血清IL-1β、IL-6和TNF-α差异具统计学意义(P＜0.05)；血清IL-1β、IL-6、TNF-α水平均与COPD抑郁的严重程度显著正相关。结论 COPD患者血清细胞因子与抑郁情绪相关。
Abstract:Objective To analysis the situation of depression in patients with chronic obstructive pulmonary disease (COPD) and the possible impact factors.Research the correlation with interleukin-1β(I L-1β),interleukin-6(I L-6),tumornecrosis factor-alpha( TNF-α) and depressioninpatientswith COPD.Methods Normal controls and COPD patients were measured with questionnaire survey and self-rating Depression Scale(SDS).Serum levels of IL-1β,IL-6,TNF-αwere measured in normal controls and COPD patients by using methodsof enzyme-linked immuno-sorbent assay( ELISA).Results The incidence of depression in patients with COPD was significantly higher than the control group; The levels of IL-1β,IL-6,TNF-αin patients without depression were muchhigher than in healthy controls,while COPD patients with depression is the most higher(P＜0. 05); The serum levels of IL-1β,IL-6,TNF-α are significant different in COPD patients with different degrees of depression. ; Serum IL-1β,IL-6 ,TNF-αlevels correlated positively and sig-nificantly with the severity of COPD.Conclusion The relationship of serum cytokine and depressionin chronic obstructive pulmonary diseaseis interrelate.
文章编号：3201810035 中图分类号：R563 文献标志码：
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