Abstract:Objective To discuss the correlation between 25-OH VitD and pregnancy induced hypertension and preeclampsia during 11-13 weeks pregnancy. Methods The serum 25-OH VitD levels in 222 cases of gestational hypertension and preeclampsia including 93 cases suffered with gestational hypertension in group A,81 cases suffered with mild preeclampsia in group B,48 cases suffered with severe preeclampsia in group C and 5958 cases of normal pregnant women during 11-13（12.70.5） weeks pregnancy were detected by chemiluminescent microparticle immunoassay. The correlation between 25-OH VitD and each group was analyzed. Results During 11-13 weeks pregnancy, the serum 25-OH VitD levels of normal pregnant women were 44.417.0 nmol/L; group A was 40.512.7 nmol/L； group B was 39.511.9 nmol/L；group C was 37.311.5 nmol/L；The serum 25-OH VitD levels had significant difference between normal pregnant women and women in group A（P<0.05）. The serum 25-OH VitD levels had significant difference between normal pregnant women and women in group B or C（P<0.01）.There was significant difference in 25-OH VitD deficiency rate（22.4%、22.6%、27.2%和22.9%）,insufficient rate（42.2%、50.5%、50.6%和58.3%）and sufficient rate（35.4%、26.9%、22.2%和18.8%）between the four groups of pregnant women（P<0.05）. There was a significant difference between the total deficiency rate and the insufficient rate（64.6%、73.1%、77.8%和81.2%,P<0.01）. Conclusion The lower level of 25-OH VitD during 11-13 weeks pregnancy is associated with gestational hypertension and preeclampsia, The lower Level of 25-OH VitD, the more serious the disease, 25-OH VitD might predict the role of gestational hypertension and preeclampsia.