Abstract:Objective To investigate the effect of periodontal foundation therapy combined with antibiotics on IL-33 and IL-6 in patients with moderate to severe chronic periodontitis.Methods 78 patients with moderate or severe chronic periodontitis admitted to our hospital from December 2016 to December 2018 were selected.According to different treatment methods, they were equally divided into control group and observation group.The control group received basic periodontal treatment, while the observation group was treated with antibiotics on the basis of the control group.The effective rate of the two groups after treatment was compared and analyzed. The levels of interleukin-33 (IL-33), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), periodontal index (GI, GI bleeding index, bleeding index after exploration) and periodontal pocket depth were measured before and after treatment for 3 months. And adverse reactions.Results The total effective rate of the observation group (94.87%) was significantly higher than that of the control group (79.48%), with statistical significance (P＜0.05). Before treatment, there was no significant difference in the levels of IL-33, IL-6, CRP, TNF-a, GI, SBI, BOP and PD between the two groups (P＞0.05). After 3 months of treatment, the levels of IL-33, IL-6, CRP, TNF-a, GI, SBI, BOP and PD in the observation group were significantly lower than those in the control group (P＜0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, with statistical significance (P<0.05).Conclusions Periodontal basic therapy combined with antibiotics can improve serum inflammatory factors and periodontal indexes in patients with moderate to severe chronic periodontitis, and the prognosis is good, which is worthy of clinical application and promotion.