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中文摘要: 目的 探索慢性持续期哮喘患者阶梯治疗中 FeNO和ACT评分、肺功能、外周血嗜酸性粒细胞动态变化的相关性。方法 纳入160名慢性持续期哮喘患者，按GINA（2014）方案给予规范治疗，每隔3个月检测患者呼出气一氧化氮（FeNO）浓度，进行ACT评分，肺功能检测以及外周血嗜酸性粒细胞计数，每3个月一次，持续1年。结果 经规范治疗，ACT评分升高，FeNO浓度下降，肺功能改善，外周血嗜酸性粒细胞计数下降，FeNO浓度与其他三者之间的动态变化有显著的相关性。结论 慢性持续期哮喘患者规范治疗后FeNO可作为哮喘控制程度的判定指标，可作为指导哮喘患者阶梯治疗调整的依据。
Abstract:OBJECTIVE Toinvestigate the dynamic changes and relationship of FeNO and ACT，Lung Function，peripheral blood eosinophils in chronic persistent asthma given with escalation therapy. METHODS 160 chronic persistent asthma patients were given with escalation therapy according to GINA（2014）.Concentration of FeNO,ACT score ，Lung Functionand peripheral blood eosinophils were evaluated for every 3 months over 1 year. RESULTS When given with escalation therapy,concentration of FeNO and peripheral blood eosinophils decreased，ACT score increased，lung function improved.There are correlation between them. CONCLUSION After the standard treatment for patients with chronic persistent asthma, FeNO can be used as the index to determine the degree of asthma control and the basis to guide the adjustment of escalation therapy for patients with asthma.
keywords: asthma FeNO escalation therapy
文章编号：3201812034 中图分类号：R1-9 文献标志码：
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