Abstract:Objective To explore the clinical effect of continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI) caused by sepsis. Methods 102 patients with AKI caused by sepsis treated in our hospital from January 2016 to January 2018 were selected as observation objects. They were randomly divided into observation group and control group with 51 cases in each group by digital table method. Both groups were given symptomatic treatment. The control group was given routine intermittent hemodialysis (IHD) treatment. The observation group was given CRRT treatment. The C-reactive protein (CRP), serum creatinine (SCr), blood urea nitrogen (BUN) and urine volume were measured before and after treatment. The recovery time of urine volume, the time of ICU treatment and the incidence of cardiovascular events were mastered. Rate of birth. Results After treatment, CRP, SCr, BUN and urine volume of the two groups were improved, but the effect of the observation group was better than that of the control group (P＜0.05). The recovery time of urine volume and hospitalization time of ICU in observation group were shorter than those in control group (P＜0.05). The incidence of cardiovascular events in the observation group was 3.92%, which was significantly lower than 15.69% in the control group (P ＜0.05). Conclusion CRRT is effective in treating AKI caused by sepsis. It can effectively remove inflammatory mediators, improve renal function and reduce cardiovascular events. It is of great clinical significance.