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中文摘要: 目的 探究丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫效果和安全性。方法 选择去年河南省直第三人民医院收治的100例脑卒中后癫痫患者，随机分为观察组和对照组，每组各50例，两组患者入院后均使用丙戊酸钠治疗，观察组在使用丙戊酸钠的基础上，联合使用左乙拉西坦治疗，对比两组患者临床疗效、治疗后6个月痫样放电、累及导联数情况和用药安全性。结果 观察组患者的治疗总有效率高于对照组，差异有统计学意义(P＜0.05)；观察组治疗后6个月痫样放电、累及导联数情况明显优于对照组，差异有统计学意义(P＜0.05)；观察组患者的总用药不良反应低于对照组，差异有统计学意义(P＜0.05)。结论 丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫，可在较短时间内缓解和终止脑卒中后癫痫的发生，有效保护脑补神经功能，药物不良反应小，安全可靠。
Abstract:OBJECTIVE To explore the efficacy and safety of valproate combined with levetiracetam in the treatment of epilepsy after stroke.METHODS 100 patients with post-stroke epilepsy admitted to our hospital last year were randomly divided into observation group and control group with 50 cases in each group. Both groups were treated with sodium valproate after admission. Combined number and medication safety.RESULTS The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05); the epileptiform discharges and the number of lead involved in the observation group were significantly better than that of the control group 6 months after treatment, the difference was statistically significant(P＜0.05); the total adverse drug reactions of the observation group were lower than that of the control group, the difference was statistically significant The difference was statistically significant(P＜0.05).CONCLUSION Sodium valproate combined with levetiracetam in the treatment of post-stroke epilepsy can alleviate and terminate the occurrence of post-stroke epilepsy in a short period of time, effectively protect the function of brain tonic nerve, drug adverse reactions are small, safe and reliable.
文章编号：3201903029 中图分类号：R742.1 文献标志码：
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| 作者 | 单位 |
| 谷丽丽① |
| Author Name | Affiliation |
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