Abstract:OBJECTIVE To study the effect of skin care model on the quality of life and prognosis of patients after anal fistula, and provide guidance for patients’ postoperative care. METHODS A total of 120 cases anal fistula patients who were treated in target hospital from June 2017 to June 2018 were enrolled in the study and divided into the observation group and the control group according to the random number table method(n=60). The control group were treated with a traditional care model, and the observation group were treated with a modified skin care model. The pruritus at 4d, 14d and 24d after operation, the incidence of eczema, the area of eczema and recovery time after 24 days, the quality of life and the incidence of complications before and after nursing intervention were compared. RESULTS At 4d, 14d and 24d after operation, the pruritus rate of the observation group (8.33%; 1.67%; 0.00%) was significantly lower than the control group (38.33%; 38.33%; 36.67%), the difference was statistically significant (P<0.05). On the 24th day after operation, the incidence of eczema in the observation group was significantly lower than the control group, and the area of eczema was small, and the recovery time were shorter, the difference was statistically significant (P<0.05). After nursing, the quality of life scores of the observation group were significantly higher than the control group; the incidence of complications in the observation group (3.33%) was significantly lower than the control group (13.33%, P< 0.05). CONCLUSION Using the modified skin care model to care for patients after anal fistula could help relieve and treat the symptoms of perianal skin eczema, protect the perianal skin, improve the quality of postoperative life, reduce the incidence of complications and help prognosis, which had clinical promotion value.