Abstract:OBJECTIVE To understand the current situation and correlation of interpersonal relationship and mental health among college students, to provide evidence for the development of mental health intervention strategies. METHODS Samples were selected by sampling method; anonymous questionnaires were conducted by using interpersonal relationship scale and general mental health scale; SPSS19.0 Software was used for data processing. RESULTS The total score of interpersonal relationship scale was 7.14±7.85, and the difference was statistically significant in family structure and grade (P<0.05). The total score of mental health scale was 4.61±3.67, and the difference was statistically significant in gender, grade, and whether or not the student leader (P<0.05). Pearson correlation analysis showed that interpersonal relationship and its dimensions were positively correlated with mental health and anxiety and depression dimensions(P<0.05), and communication and friendship, conversation dimension were positively correlated with self-denial dimension (P< 0.05). The results of multiple linear regression analysis showed that interpersonal relationships and their dimensions could predict the mental health status as 16.7%~49.8%. CONCLUSION The interpersonal relationship of college students was closely related to mental health. Improving the interpersonal ability could improve their mental health. It was recommended that school educators should pay attention to cultivating and guiding students to establish correct interpersonal values ​​and promote the overall healthy growth of college students.