Abstract:OBJECTIVE To investigate the clinical efficacy of early repeated high dose naloxone in the treatment of severe CO poisoning. METHODS 64 patients with severe carbon monoxide poisoning were selected from the emergency department of Qingyang People's Hospital. According to the random number table method, the patients were divided into control group and observation group, 32 cases in each group. The control group was treated with hyperbaric oxygen combined with mannitol, vitamin C and Xingnaojing. On the basis of routine treatment, the observation group was treated with repeated high-dose naloxone. Glascow coma score, Barthel index, mortality, recovery time and incidence of delayed encephalopathy within 3 months after recovery were compared between the two groups.RESULTS The total effective rate of the observation group (87.50%) was higher than that of the control group (62.50%). After treatment, the Glascow coma score and Barthel index were better than the control group in the observation group; the mortality rate of the observation group was 6.25%, lower than the control group. 25.00% of the group; the recovery rate of the observation group was 87.50% within 72 hours, which was higher than that of the control group (75.00%), the difference was statistically significant (P<0.05). Within 3 months, 2 patients (6.25%) had delayed encephalopathy in the observation group, and 9 patients (28.13%) had delayed encephalopathy in the control group. The incidence was statistically significant (χ2) =5.379, P=0.020).CONCLUSION Early high dose naloxone is effective in treating acute CO poisoning. It can effectively improve coma, shorten coma time, reduce mortality and risk of delayed encephalopathy, and improve prognosis of patients.