Abstract:OBJECTIVE Follow-up and family intervention for children with early warning signs of autism in their first year of age，to explore the relationship between autism screening results and intelligence development in children with clinical manifestations but without family intervention. METHODS Using the Guidelines for Diagnosis, Treatment and Rehabilitation of Children with Autism promulgated by the Ministry of Health, children with early warning signs at the age of 1 (experimental group) and children with clinical manifestations of autism at the age of 18-24 months (control group) were screened out，the CHAT-23 scale and the Child Heart Scale were assessed in 18~24 months，the results were compared and analyzed. RESULTS The number of suspicious and abnormal results of CHAT-23 scale screening in the experimental group was significantly lower than that in the control group, there were significant differences between the two groups (P＜0.05); The total developmental quotient of both groups was lower than that of normal children, however, children in the control group lagged behind significantly, the backwardness of language and social communication is obvious, there was no significant difference between the two groups except for big exercise and language (P＞0.05), there were significant differences in other groups (P＜0.05); Comparison of single positive rate of CHAT-23 scale in two groups of children, it was found that there were significant differences among the groups (P＜0.05), and there are significant differences among the seven core projects. CONCLUSION Early screening for children with early warning signs of autism, early family intervention, to some extent, it can improve the prognosis of autistic children, and improve their intelligence development level.