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中文摘要: 目的 观察儿童维生素AE缺乏与呼吸道感染的相关性和补充治疗儿童呼吸道感染的疗效与安全性。方法 选取128例反复呼吸道感染患儿，随机分为常规组和联合组。常规组给予常规抗感染治疗，联合组则额外给予补充维生素AE治疗，50例健康儿童设为对照组。观察三组儿童血清维生素A、E和免疫球蛋白水平，分析维生素AE缺乏与反复呼吸道感染的相关性，评价临床治疗效果，比较不良反应及复发率。结果 128例患儿维生素A、E缺乏检出率分别为86.72%和48.44%，明显高于健康儿童（6.00%和4.00%），组间差异比较（P＜0.05）；维生素A、E均和儿童反复呼吸道感染呈明显的负相关（r=-0.570和-0.423）；联合组治疗后血清维生素AE水平及血清IgA、IgG、IgM水平高于常规组（P＜0.05）；常规组和联合组临床治疗显效率分别为76.56%和92.19%（P＜0.05）；联合组患儿发热、咳嗽、扁桃体肿大、肺部啰音症状消失时间均短于常规组（P＜0.05）；常规组和联合组随访1年复发率分别为21.86%和6.25%（P＜0.05）。结论 维生素AE缺乏可增加反复呼吸道感染的发生风险，补充维生素AE可提高临床疗效，改善患儿免疫功能，降低复发率，安全可靠。
Abstract:OBJECTIVE To observe the relationship between vitamin AE deficiency and respiratory tract infection in children, and to analyze the clinical effect and safety of vitamin AE supplementation in children with respiratory tract infection. METHODS 128 children with recurrent respiratory infection were randomly divided into the conventional group and the combined group. The conventional group received conventional anti-infective treatment, and the combined group received additional vitamin AE treatment.50 healthy children were randomly selected as the control group.Three groups of children were tested for serum vitamin A, E levels and immunoglobulin levels before and after treatment.Perason correlation coefficient analysis of the association between vitamin AE deficiency and recurrent respiratory infections.The clinical treatment effects of the children in the conventional group and the combined group were evaluated. The disappearance time, adverse reactions and recurrence rate of clinical symptoms were compared between the two groups. RESULTS The detection rates of vitamin A and E deficiency in 128 children were 86.72% and 48.44%, respectively, which were significantly higher than those in healthy children (6.00% and 4.00%). The differences between groups were compared (P<0.05).Vitamin A and E were significantly negatively correlated with repeated respiratory infections in children (r=-0.570 and -0.423).Serum vitamin AE levels and serum IgA, IgG, IgM levels were higher in the combined group than in the conventional group (P<0.05).The effective rates of clinical treatment in the conventional group and the combined group were 76.56% and 92.19%, respectively (P＜0.05).The fever, cough, tonsil enlargement, and disappearance of lung vocal symptoms were shorter in the combined group than in the conventional group (P＜0.05).The 1-year recurrence rates of the conventional group and the combined group were 21.86% and 6.25%, respectively (P＜0.05). CONCLUSION Vitamin AE deficiency is closely related to the occurrence of repeated respiratory infections in children. Supplementation of vitamin AE on the basis of conventional anti-infective treatment can significantly improve the clinical treatment effect, improve the immune function of children, shorten the symptom improvement time, reduce the recurrence rate, and be safe and reliable.
keywords: children respiratory tract infection vitamin A vitamin E correlation immune function ecurity
文章编号：3202004014 中图分类号：R1-9 文献标志码：
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