Abstract:OBJECTIVE To understand the current situation of birth defects in Chaoyang District of Beijing by analyzing the monitoring results of birth defects from 2015 to 2019. MRTHODS Based on the hospital monitoring method，the monitoring data of all the children with birth defects reported were analyzed，and the changes over the years were compared. RESULTS From 2015 to 2019 in Chaoyang District, the average incidence of birth defects was 37.35‰ during the whole pregnancy period. The incidence remained stable from year to year. The average incidence of birth defects in the perinatal period was 27.86‰. The incidence of perinatal birth defects increased in recent two years. In 2019, other chromosomal abnormalities entered the top 5 for the first time, the incidence was increased by 94% from 2015. In the past two years, more than 90% of cases of down syndrome and neural tube defects were induced before perinatal period. CONCLUSION The incidence of birth defects in Chaoyang District was lower than the national average level, and the improvement of prenatal screening and prenatal diagnosis techniques in recent years played a positive role in early detection of severe malformation and prevention of perinatal period. At present, the incidence of congenital heart disease ranked the first proportion, and the incidence of chromosomal abnormalities was also on the rise. Therefore, comprehensive prevention and treatment of birth defects should be done well, the application of high-throughput sequencing technology should be standardized.