Abstract:OBJECTIVE To understand the epidemic situation of Hand-foot-mouth disease (HFMD) in Qinzhou from 2009 to 2020, so as to provide scientific basis for the future prevention and control of hand-foot-mouth disease (HFMD). METHODS The in⁃ formation of HFMD and enterovirus 71(EV71) vaccine data were obtained from the Chinese Disease Prevention and Control Informa⁃ tion System and the Childhood Immunization Program Information System, and descriptive epidemiological analysis was conducted. RESULTS 60 652 cases of HFMD were reported from 2009 to 2020, including 1 493 severe cases and 21 deaths. The average annu⁃ al incidence rate was 157.14 /100 000, the severe cases rate and fatality rate were 2.46% and 0. 03%. Cases in children aged 5 or younger accounted for 92.89%. The male was more than the female (χ2=2169.19, P＜0.05). The male-to-female ratio was 1.68:1. The scattered children and the kindergarten children accounted for 88.27% and 8.97%. Two peaks of incidence were observed every year expect 2017 and 2019, with the highest occurring between April and July and the second occurring between September and Oc⁃ tober. In terms of the etiological characteristics, the dominant pathogens changed annually. The dominant pathogen in severe and fa⁃ tal cases was the EV71 with only 18.50 percent of vaccine coverage. CONCLUSION There were obvious seasonal and regional differ⁃ ences in the distribution of HFMD in Qinzhou, and the dominant pathogens had changed in recent years. The Scattered children and the kindergarten children were high risk groups. Therefore, it should promote the vaccination of HFMD EV71 vaccine, intensify ef⁃ forts to publicize education and strengthen the monitoring and the pathogen typing surveillance, effective handling and control of the epidemic.