Abstract:OBJECTIVE To explore the main factors influencing recurrence of colorectal adenomatous polyps after endoscopic resection, and by using regression analysis. METHODS Clinical data of 1 025 cases of patients treated with endoscopic resection of colorectal adenomatous polyps in our hospital were analyzed retrospectively, and recurrence rate was figured. Statistical software (SPSS 19.0 version) was used to analyze the factors related to postoperative recurrence by single factor analysis and multi-factors Logistic regression analysis. RESULTS Among 1025 cases of patients, there were 277 cases recurrence, with the rate of 27.02%. There were significantly differences in recurrence rate between age more than or equal to 65 and less than 65, the number of adenomas more than or equal to 3 and less than 3, adenoma diameter more than or equal to 6mm and less than 6mm, located in sigmoid colon and rectum and ascending colon, basal portion of adenoma and basal stalk and artie, intestinal cleaning of Class Ⅱ and classⅠ, advanced and low-grade neoplasia, all and partial resection, villous and tubular adenoma (P < 0.05). Factors influencing recurrence of endoscopic resection of colorectal adenomatous polyps were adenoma type （OR=3.531）, tumor extent（OR=1.258）, basal adenoma（OR=2.331） age （OR=1.282）, adenoma diameter (OR=1.295), intestinal cleanliness （OR=3.386）.CONCLUSION There are many factors influencing the recurrence of colorectal adenomatous polyps after endoscopic resection, and it should be based on specific conditions of patients to develop personalized follow-up program.