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中文摘要: 目的 探讨外周血指标检测在急性缺血性脑卒中(AIS)深静脉血栓(DVT)中的诊断价值。方法 根据血栓形成情况，将410例AIS患者分为血栓组(n＝210)和无血栓组(n＝200)，另将180例体检健康者设为对照组，检测各组外周血P-选择素、D-二聚体、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平。结果 血栓组平均年龄明显高于无血栓组(P＜0.05)；血栓组D-二聚体、P-选择素水平均明显高于无血栓组与对照组(P＜0.05)；血栓组的hs-CRP水平明显高于对照组(P＜0.05)；无血栓组的D-二聚体、P-选择素及hs-CRP水平明显高于对照组(P＜0.05)；三组Hcy水平无明显差异(P＞0.05)。联合应用后，检测的灵敏度为70.6%，特异度为96.6%。结论 P-选择素和D-二聚体联合检测在诊断AIS DVT方面具有较高价值。
Abstract:OBJECTIVE To explore the diagnostic value of peripheral blood detection in deep vein thrombosis (DVT) in acute hemorrhagic cerebral stroke (AIS). METHODS A total of 410 patients with AIS were divided into thrombus group (n＝210) and non-thrombus group (n＝200) according to the formation of thrombus, and another 180 healthy people undergoing physical examinations served as control group. The levels of P- selectin, D-dimer (D-D), homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) in the peripheral blood of all groups were detected. RESULTS Thrombus group were evidently higher in average age (P＜0.05), and notably higher in the levels of D-D and P- selectin than non-thrombus group (P＜0.05). Thrombus group was prominently higher in the level of hs-CRP than control group (P＜0.05), while non-thrombus group was significantly higher in D-D, P- selectin and hs-CRP levels than control group (P＜0.05). There was insignificant difference among three groups in Hcy level (P＞0.05). After combined application, the sensitivity and specificity of detection was 70.6% and 96.6%, respectively. CONCLUSION Combined detection of P- selectin and D-D has higher value in the diagnosis of AIS DVT.
文章编号：3201712048 中图分类号：R743 文献标志码：
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