Abstract:OBJECTIVE To investigate the relationship between serum homocysteine, glycosylated hemoglobin and uric acid with coronary artery disease in patients with type 2 diabetes mellitus combined with coronary heart disease. METHODS 118 cases with type 2 diabetes in our hospital during January 2015 to January 2016 were selected and according to the patient's examination results were divided into diabetes mellitus group (A group with 45 cases) and diabetes mellitus complicated with coronary heart disease group (B group with 73 cases). 55 cases of healthy residents at the same time underwent the routine examination were selected as the control group. The clinical data of the three groups were compared and the correlation of Hcy, HbAlc, UA and coronary artery disease in diabetic patients was analyzed. RESULTS The age, gender, smoking, BMI, TC, TG, LDL-C, HDL-C, UA, folic acid, vitamin B12, hemoglobin was no significantly different among three groups (P>0.05). The expression level of Glu in B group were significantly higher than those in control group and A group (P<0.05). The expression level of HbAlc in B grous with ACS were significantly higher in the B group with SAP, control group and A group (P<0.05). the Logistic regression analysis showed that Hcy, HbAlc and UA were risk factors for coronary artery disease. CONCLUSION The levels of serum Hcy, HbAlc and UA are positively related to coronary artery disease in patients with type 2 diabetes mellitus complicated with coronary heart disease. The degree of coronary artery disease is higher with the increase of serum levels of Hcy, HbAlc and UA.