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中文摘要: 目的 探讨老年2型糖尿病患者（type 2 diabetes mellitus，T2DM）血清尿酸（serum uric acid，SUA）水平与周围神经并发症（diabetic peripheral neuropathy, DPN）的关系。方法 选取2015年1月—2016年12月在×医院内分泌科住院及门诊就诊的T2DM患者共843例，对入选患者根据临床表现和检查结果进行DPN诊断，并将患者分为DPN组和非DPN组，收集患者一般资料及病史并采集血清进行SUA等生化指标检测，按四分位法将SUA水平分为4组以及采用多因素logistic回归分析方法分析USA与DPN发生的关系。结果 DPN患者SUA水平为（411.5±106.3）μmol/L，明显高于非DPN患者的（296.2±87.3）μmol/L，差异有统计学意义（P<0.05）；随着SUA水平的升高，DPN发生率也随之升高，差异有统计学意义（P<0.05）；DPN发生的多因素logistic回归分析显示，SUA的OR 及95% 可信区间（CI）为3.013 (1.966，10.216)。结论 SUA是DPN发生的一个独立危险因素，SUA水平可作为预测T2DM患者发生DPN的重要参考指标。
Abstract:OBJECTIVE To study the correlation of serum uric acid (SUA) level in old type 2 diabetes mellitus (T2DM) patients with diabetic peripheral neuropathy (DPN). METHODS A total of 843 T2DM in- and out-patients in endocrinology department of ×× hospital from January 2015 to December 2016 were enrolled in this study. DPN was diagnosed by neuropathy symptom and neuropathy disability, and the T2DM patients were divided into DPN group and no-DPN group. The general information and medical history of patients were collected, biochemical parameters including SUA were measured. The subjects were stratified according to quartiles of SUA levels. Logistic regression analysis was used to analyze odds ratios between SUA and the prevalence of DPN. RESULTS The level of SUA in DPN group (411.5±106.3μmol/L) was higher than that of no-DPN group (296.2±87.3μmol/L) significantly (P<0.05); As the level of SUA rise, the prevalence of DPN increased (P<0.05); The OR and 95% CI of SUA to DPN was 3.013 (1.966-10.216). CONCLUSION The level of SUA was one independent risk factor of DPN, it can be a important reference index to predict the prevalence of DPN.
keywords: diabetes mellitus type2 uric acid diabetic neuropathies
文章编号：3201801021 中图分类号：R587.1 文献标志码：
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