Abstract:OBJECTIVE To analyze the diagnostic value of transcranial Doppler ultrasonography (TCD) combined with carotid artery ultrasound in ischemic cerebrovascular disease (ICVD). METHODS A total of 93 patients with ICVD were selected and treated with digital subtraction angiography (DSA), TCD and carotid artery ultrasound, with DSA results as the diagnostic criteria. The examination results of single TCD, single carotid artery ultrasound and TCD combined with carotid artery ultrasound were compared, and their sensitivity, specificity, positive predictive valve (PPV) and negative predictive value (NPV) in the diagnosis of ICVD were analyzed. RESULTS DSA showed 763 abnormal intra- and extra-cranial vessels in the patients, while single TCD revealed 73 abnormal intracranial vessels and 294 abnormal extracranial vessels, single carotid artery ultrasound indicated 64 abnormal intracranial vessels and 275 abnormal extracranial vessels, and TCD combined with carotid artery ultrasound suggested 89 abnormal intracranial vessels and 569 abnormal extracranial vessels in total. TCD combined with carotid artery ultrasound was evidently higher than single TCD and single carotid artery ultrasound in sensitivity, specificity, PPN and NPV in the diagnosis of ICVD. CONCLUSION TCD combined with carotid artery ultrasound can promote the accuracy in the diagnosis of ICVD, thus can be used as an effective examination method for the diagnosis of intra- and extra-cranial vascular diseases.