Abstract:OBJECTIVE To evaluate the clinical value of aspirin combined with Clopidogrel in treatment of progressive cerebral stroke. METHODS A total of 73 patients with progressive cerebral stroke was selected and randomly divided into treatment group(n=37) and control group (n=36). Control group was treated with aspirin, while treatment group with aspirin combined with Clopidogrel. The clinical efficacy, the changes of neurological deficit score, activities of daily living (ADL) and high-sensitivity C-reactive protein(hs-CRP)level before and after treatment, and the occurrence rates of adverse reactions were observed in both groups. RESULTS The total response rate(RR) was 91.89% in treatment group, evidently higher than the 72.22% in control group(P＜0.05). National Institutes of Health Stroke Scale (NIHSS) score was decreased evidently while ADL score was increased notably on post-treatment d7 and 14(P＜0.05orP＜0.01),but the decrease and increase amplitudes were more significantly in treatment group than those in control group on postoperative d14(P＜0.05). Compared with treatment before, hs-CRP level was increased markedly on postoperative d7 and was decreased notably on postoperative d14 in both groups(P＜0.01), but the decrease amplitude on postoperative d14 was more significant in treatment group than that in control group on postoperative d14 (P＜0.05). During treatment, no significant adverse reactions were found in either group. CONCLUSION Early application of aspirin combined with Clopidogrel can effectively relieve the clinical symptoms, increase ADL, and reduce hs-CRP level with significant clinical efficacy in the treatment of patients with progressive cerebral stroke.