Abstract:OBJECTIVE To explore the influence of fast-track surgery (FTS) strategies in anesthetic management on stress response of patients with laparoscopic surgery for rectal cancer. METHODS A total of 96 patients who received laparoscopic radical resection for rectal cancer on selective days were selected and randomly divided into FTS group and control group, 48 cases for each group. FTS group received a series of FTS strategic anesthetic management, while control group received routine anesthetic management. Peri-operative related indicators were compared between two groups, and stress factor levels, T lymphocyte subgroup levels and occurrence rates of surgical complications were observed before and after surgery. RESULTS FTS group was markedly shorter than control group in anus aerofluxus time and the length of hospital stays, and there were significant differences (P＜0.05). C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and adrenocorticotrophic hormone (ACTH) levels were increased prominently on postoperative d1 and d3 than those at preoperative d1 (P＜0.01), but they were significantly lower in FTS group than those in control group on postoperative d3 (P＜0.05). On postoperative d3, FTS group was notably higher than control group in CD3+, CD4+ and CD4+/CD8+ levels, and there were significant differences (P＜0.05 or P＜0.01). There was insignificant difference between two groups in the occurrence rates of complications (P＞0.05). CONCLUSION Application of FTS strategies in anesthetic management can effectively relieve the stress response severity and protect the body immune function, thus becoming beneficial to the postoperative fast rehabilitation of patients with laparoscopic surgery for rectal cancer.