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中文摘要: 目的 分析GnRHa对女性恶性肿瘤患者化疗过程发挥的卵巢功能保护作用。方法 将我院2012年1月—2016年2月收治的女性恶性肿瘤患者60例，随机分成两组，每组各30例。对照组进行常规化疗，观察组在对照组基础上联合应GnRHa (达菲林)化疗。观察并对比两组患者治疗前后性激素水平、月经恢复情况、卵泡监测情况、妊娠及生育情况。结果 化疗后3个月观察组FSH、LH水平显著低于对照组治疗后，E2、AHM水平显著高于对照组治疗后(P＜0.05)，并随着化疗后时间延长对照组FSH、LH逐渐升高，AMH明显下降；GnRHa组化疗后6月恢复正常月经的比例100.0%，而对照组恢复正常月经的比例为60%，两组恢复正常月经比例的比较差异有显著性；观察组自然妊娠率为62.5%，对照组自然妊娠率为40.0%，两组对比差异有显著性，两组复发率比较差异无统计学意义。结论 GnRHa对女性恶性肿瘤患者化疗期间卵巢功能具有保护作用，提高治疗后正常月经恢复率，提高妊娠率，但仍需长期随访及大规模临床试验以验证。
中文关键词: 促性腺激素释放激素激动剂 化疗 卵巢功能 恶性肿瘤
Abstract:OBJECTIVE To observe the clinical effect of gonadotropin-releasing hormone agonists (GnRHa) cotreatment during chemotherapy in malignant tumor patients. Methods Sixty cases of female patients with malignant tumour admitted to our hospital from January 2012 to February 2016 were selected and randomly divided into two groups，with 30 cases in each group. The control group was given routine chemotherapy，while the observation group was given Diphereline on the basis of routine chemotherapy．The hormones levels were detected Before chemotherapy and after chemotherapy. The situation of menstruation and Pregnancy were observed. Results Three months after therapy，The FSH level and LH level of observation group were significantly lower than those of control group，and the E2、AHM level was significantly higher than that of control group(all P＜0.05)．All of the women(100. 0%) in the study group compared with the patients in the controlgroup( 60%) resumed normal menses 6 months after the termination of the treatment(P＜0.05)．In the study group( natural pregnancy rate: 62.5%) while in the control group( naturalpregnancy rate: 40%) (P＜0. 05)，There was no significant difference in the recurrence rate between the two groups.CONCLUSIONS GnRHa has protective effect on ovarian function of female patients with malignant tumour during chemotherapy，which can maintain the normal levels of sex hormones and menstrual cycle，improve patients’quality of life，and a better pregnancy rate.Long-term follow up and large scale clinical studies are required to confirm the conclusion．
文章编号：3201805009 中图分类号：R1-9 文献标志码：
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