Abstract:OBJECTIVE To investigate the effect of comprehensive nursing intervention on depression and quality of life in depressed patients in community. METHODS 306 elderly patients with depression were randomly divided into control group and intervention group according to the random number table method. There were 153 cases in each group, with 51 samples of light, medium and heavy. The control group did not take any measures except for taking antidepressants. Intervention group: In addition to taking antidepressants, the patients were given mild, moderate and severe interventions at different levels. The community physicians intervened every two weeks and were related record of. All patients were enrolled at the 6th, 12th, 24th and 48th week of follow-up. The Hamilton Depression Rating Scale was assessed. Community assessment physicians were trained in psychology and were evaluated every six months. All patients were enrolled in the study and followed up After the 48th week, the second edition of the Health Questionnaire (SF-36V2) survey was conducted; the two groups were evaluated. RESULTS The HAMD score decreased gradually from the 6th weekend to the 48th weekend in the intervention group (P﹤0.05), but the score of the control group did not change significantly (P﹥0.05). The HAMD score of the intervention group from the 6th week to the 48th week was significantly lower than that of the control group , The differences were statistically significant, P<0.05. At the end of the follow-up period of 48 weeks, there were significant differences between the two groups of senile depression in effective rate and significant effective rate, P<0.05. The scores of MHD, RE, VT, GH, BP and SF6 dimensions in intervention group at the end of the 48th week after intervention were higher than those before intervention, P<0.05 ; The control group did not change significantly, P>0.05. At the end of the 48th week, the scores of MH, RE, VT, GH, BP and SF in health-related quality of life in the intervention group were all higher than those in the control group (P﹤0.05). CONCLUSION The implementation of comprehensive nursing intervention can contribute to the improvement of depressive symptoms and improve the quality of life in the elderly patients with depression in the community.