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中文摘要: 目的 探讨幽门螺杆菌(HP)感染与阿司匹林对消化性溃疡的协同致病作用。方法 选取上海市彭浦新村街道社区卫生服务中心消化科于2014年6月—2017年6月门诊及住院收治的38例消化性溃疡的患者作为研究对象作为观察组；将同期就诊的38例非消化性溃疡患者作为对照组，对两组患者的HP感染和服用阿司匹林的情况进行检测，并分析其对消化性溃疡的协同致病作用。结果 单纯服用阿司匹林者：胃溃疡OR值为5.72，十二指肠溃疡OR值为5.68；单纯HP感染者：胃溃疡OR值为5.58，十二指肠溃疡OR值为19.47；服用阿司匹林且伴HP感染者：胃溃疡OR值为15.22，十二指肠溃疡OR值为24.41。不规律服药组及规律服药组与未服药的无溃疡患者相比较，P＞0.05，差异无统计学意义。结论 服用阿司匹林与感染HP在胃溃疡中有一定协同作用。
Abstract:OBJECTIVE To investigate the synergistic effect of Helicobacter pylori (HP)infection and aspirin on peptic ulcer.METHODS 38 patients with peptic ulcer treated in the Department of Gastroenterology of Xinpu Street Community Health Service Center in Pengpu, Shanghai, from June 2014 to June 2017 as the study group; as the observation group, 38 cases of non-digestion during the same period As a control group, ulcer patients were tested for HP infection and aspirin use in both groups, and their synergistic pathogenic effects on peptic ulcer were analyzed.RESULTS Patients who simply took aspirin: OR value of gastric ulcer was 5.72, OR value of duodenal ulcer was 5.68; those with simple HP infection: OR value of gastric ulcer was 5.58, OR value of duodenal ulcer was 19.47; aspirin was taken with HP infection The OR value of gastric ulcer was 15.22, and the OR value of duodenal ulcer was 24.41. Irregular medication group and regular medication group compared with non-dosage non-ulcer patients, P> 0.05 (the difference was not statistically significant).CONCLUSION Taking aspirin and infecting HP has a synergistic effect in gastric ulcers.
keywords: peptic ulcer aspirin helicobacter pylori
文章编号：3201806030 中图分类号：R573.1 文献标志码：
基金项目:
| 作者 | 单位 |
| 陆霞芳① , 闵 敏② |
| Author Name | Affiliation |
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