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中文摘要: 目的 观察左卡尼汀联合前列地尔对冠心病合并2型糖尿病患者血液流变学、IMT及血清APN、Hcy的影响。方法 选取我院2015年4月—2016年10月收治的冠心病合并2型糖尿病患者106例，将其分为研究组和对照组各53例。对照组在常规治疗基础上给予前列地尔治疗，研究组在对照组基础上加用左卡尼汀治疗，观察两组治疗前后患者血液流变学、颈动脉内中膜厚度(Intima-media thickness,IMT)及血清脂联素(Adiponectin,APN)、同型半胱氨酸(Homocysteine,Hcy)水平变化情况，比较两组的总有效率和不良反应情况。结果 治疗后两组患者血浆黏度、红细胞压积、红细胞变形指数和纤维蛋白原等血液流变学指标水平均比治疗前明显改善，且研究组优于对照组(P＜0.05)；治疗后两组IMT厚度比治疗前无显著增加(P＞0.05)；治疗后两组患者血清APN水平比治疗前显著升高(P＜0.05)，Hcy水平均显著降低(P＜0.05)，且研究组优于对照组(P＜0.05)；研究组总有效率为94.34%，明显高于对照组79.25%(P＜0.05)；研究组不良反应率为13.21%，与对照组11.32%无明显差异(P＞0.05)。结论 左卡尼汀联合前列地尔治疗冠心病合并2型糖尿病，能改善血液流变学指标，稳定患者IMT厚度，提高血清APN水平，降低血清Hcy水平。
Abstract:OBJECTIVE To observe the influence of L-carnitine combined with alprostadil on Hemorheology, IMT and serum APN, Hcy of patients with coronary heart disease complicated with type 2 diabetes. METHODS 106 cases of patients with coronary heart disease complicated with type 2 diabetes treated in our hospital from April 2015 to October 2016 were selected, and were divided into study group and control group randomly, 53 cases in each group. The control group were given alprostadil treatment on the basis of routine treatment, and the study group were added L-carnitine treatment on the basis of the control group. Blood rheology, carotid intima-media thickness (IMT), serum adiponectin (APN) and homocysteine (Hcy) levels were observed before and after treatment in the two groups, and the total effective rate and adverse reaction were compared in the two groups. RESULTS After treatment, plasma viscosity, hematocrit, erythrocyte deformability index, fibrinogen and other indexes of hemorheology significantly improved in the two groups, and those in the study group were better than those in the control group(P＞0.05). Serum APN level was significantly higher than that before treatment(P＜0.05), and Hcy level was significantly lower(P＜0.05), and the study group was better than the control group (P＜0.05). IMT thickness was not significantly increased when compared with that
before treatment(P＜0.05). Serum APN level was significantly higher than that before
treatment (P＜0.05), and Hcy decreased significantly (P＜0.05), and those in the study group were better than those in the control group (P＜0.05). Total effective rate of the study group was 94.34%, significantly higher than that of 79.25% of the control group (P＜0.05). The adverse reaction rate of the study group was 13.21%, with no significant difference when compared with that of 11.32% of the control group (P＞0.05). CONCLUSION L-carnitine combined with Alprostadil can improve hemorheology index, make patients’ IMT thickness stable, improve serum APN level, and reduce serum Hcy level.
keywords: Coronary heart disease with type 2 diabetes mellitus L-carnitine Alprostadil Hemorheology IMT APN Hcy
文章编号：3201806029 中图分类号：R573.1 文献标志码：
基金项目:
| 作者 | 单位 |
| 戴 慧① ,倪天兴② |
| Author Name | Affiliation |
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