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中文摘要: 目的 探讨农牧区蒙古族人群血管紧张素II(Ang II)、血浆肾素活性(PRA)与胰岛素抵抗(IR)的关系。方法 选取2 553例20岁及以上的蒙古族居民为研究对象，调查、收集居民的人口统计学和生活方式危险因素资料，测量血压、身高和体重，采集血标本检测血脂、血糖、胰岛素、Ang II和PRA等指标。运用logistic回归模型分析Ang II、PRA水平与胰岛素抵抗的关系。结果 胰岛素抵抗组的Ang II 、PRA水平显著高于正常组(P<0.05)。无论是年龄性别调整，还是多因素调整，随着AngII和PRA水平的增高，胰岛素抵抗的危险性均呈现增加的趋势(P<0.05)。以最低分位为参比， Ang II最高分位发生胰岛素抵抗的OR(95%CI)为1.43(1.10,1.85)，PRA最高分位发生胰岛素抵抗的OR(95%CI)为1.46(1.12,1.91)。结论 Ang II水平、PRA均与胰岛素抵抗存在关联。
中文关键词: 蒙古族 Ang II 肾素-血管紧张素系统 胰岛素抵抗
Abstract:OBJECTIVE To explore the relationship between angiotensin II (Ang II) ,plasma renin activity (PRA) and Insulin resistance(IR) among Mongolian population. METHODS 2 553 Mongolians aged 20 and over were served as study subjects, demographic data and lifestyle risk factors were collected, blood pressure, body height and weight were measured, and blood samples were collected to examine blood lipids, fasting plasma glucose, insulin, Ang II and PRA for all subjects. Logistic regression was used to analyze the association between Ang II and PRA and IR among Mongolians. RESULTS The average levels of Ang II and PRA were significantly higher in the IR group than normal group. Whether it was age-gender-adjusted or multi-factor-adjusted, the risk of IR (HOMA-IR>3.42) increased with increased level of Ang II and PRA (P <0.05 for trend test). Compared to the lowest quartile, the multivariable-adjusted odds ratio ( 95% confident interval) for the highest quartiles of Ang II and PRA was 1.43(1.10,1.85) and 1.46(1.12,1.91), respectively. CONCLUSION Ang II and PRA were significantly associated with IR among Mongolians.
文章编号：3201812013 中图分类号：R587 文献标志码：
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| 作者 | 单位 |
| 韦晓淋①#，张永红 |
| Author Name | Affiliation |
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