Abstract:Objective To understand the health literacy status of residents in Zhuhai and its influencing factors, and to provide scientific basis for formulating effective intervention strategies for health education in the future.Methods A questionnaire survey on health literacy of 3 909 residents aged 15 to 69 years old in Zhuhai was carried out by multi-stage stratified cluster random sampling method. Results The health literacy level of Zhuhai residents was 23.9%, the basic knowledge concept, healthy life style and behavior, basic skills were 43.1% 17.8% and 29.2% respectively. The health problem literacy were safety and first aid literacy(64.8%), scientific health literacy(50.7%), health information literacy(36.0%), basic medical literacy (27.8%), infectious disease prevention(24.6%) and chronic disease prevention(20.4%). The results of Logistic regression analysis showed that gender, education, occupation, family population and annual family income were the important factors influencing the health literacy of Zhuhai residents. Conclusion The level of health literacy of residents in Zhuhai was higher than China, but it needed to be further improved. It was necessary to carry out targeted intervention according to the characteristics of key population groups and strengthen health education on weak health knowledge points such as the prevention and treatment of chronic diseases, so as to improve the level of residents’ health literacy.