Abstract:OBJECTIVE To understand the status of Sub-health among different professional populations in Hongkou District, Shanghai, in order to provide the evidence for formulating intervention strategies. METHODS A total of 1 931people(including police, teachers of primary and middle school, doctors of CDC and community health service centre, civil servant) were selected conduct the investigation by cluster random sampling. RESULTS 1 770 eligible questionnaires were collected. The incidence rate of sub-health was 72.66%. Single factor analysis showed that the sub-health incidence rate were different if occupation, age, marital status, sleeping time, how late you stay up, drinking condition, smoking condition, eat regular situation, body shape, physical training, work overtime，work with computer, occupational stress, self-assessment of physical and psychological health were different(P＜0.05). Unconditional logistic regression analysis showed that marital status, occupation, average daily sleep time, how late you stay up, physical training, work overtime and scores of pressure evaluation, self-assessment of physical and psychological health were risk factors of sub-health(P＜0.05). CONCLUSION The factors of marital status, occupation and social environment were the important facts to lead to sub-health. It was suggest that this group of people should be given health education by means of the support from society, government and family to adjust their style of work, life and behavior manners, and thus preventing sub-health and stopping development of disease.