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中文摘要: 目的 探讨小青龙汤加减治疗急性呼吸窘迫综合征的临床疗效,为疾病的诊治提供临床依据。方法 收集于2017年4月—2018年10月在我院呼吸科治疗的急性呼吸窘迫综合征患者86例，采用随机数表法将随机分为对照组和治疗组，每组各43例。对照组采取常规治疗，包括抗炎治疗、机械通气治疗、调节体内水电解质及酸碱度平衡、防止如应激性溃疡等并发症的发生和基础性营养维持等。治疗组患者在对照组常规治疗的基础上，口服小青龙汤加减治疗，嘱患者于每日早、晚饭后半小时温服，每次服用100 ml。分别对两组患者进行为期14 d的持续性治疗。经过14 d治疗后进行疗效评估，观察治疗后两组患者的中医证候评分、急性生理慢性健康状况评分、炎性因子和血气分析变化情况。结果 治疗后两组患者的TNF-α和IL-6较治疗前均有改善，且治疗组明显优于对照组，差异有统计学意义(P＜0.05)，两组的中医证候评分、血气分析、急性生理慢性健康状况评分较治疗前均有改善，且治疗组明显优于对照组，差异有统计学意义(P＜0.05)。结论 采用小青龙汤加减治疗急性呼吸窘迫综合征，可以通过发挥其温中散寒、化饮止咳的作用抑制炎性反应的发生，缓解支气管痉挛，延缓肺组织损伤，进而显著提高临床疗效，减少患者痛苦。
Abstract:OBJECTIVE To investigate the clinical efficacy of Xiaoqinglong Decoction in the treatment of 86 cases of acute respiratory distress syndrome, and to provide clinical evidence for the diagnosis and treatment of the disease. METHODS A total of 86 patients with acute respiratory distress syndrome who were treated with respiratory disease in target hospital from April 2008 to October 2018 were randomly divided into control group and treatment group, with 43 patients. Patients in the control group were treated routinely, including anti-inflammatory therapy, mechanical ventilation therapy, regulation of water, electrolytes and pH balance in the body, prevention of complications such as stress ulcers, and maintenance of basic nutrition. The patients in the treatment group were treated with Oral Xiaoqinglong Decoction on the above-mentioned conventional treatment of the control group. The patients were treated with Shuijianbi every morning and half an hour after supper, taking 100ml each time. The two groups of patients were treated with continuous treatment for 14 days. The therapeutic effect was evaluated after 14 days of treatment, and the TCM syndrome score, acute physiological chronic health status score, inflammatory factor and blood gas analysis changes of these two groups were observed. RESULTS After treatment, TNF-α and IL-6 were improved in both groups, and the treatment group was significantly better than the control group after treatment. The difference was statistically significant (P<0.05). Waiting score, blood gas analysis, acute physiological chronic health status scores were also improved compared with before treatment, and the treatment group was significantly better than the control group after treatment, the difference was statistically significant(P<0.05). CONCLUSION Xiaoqinglong Decoction could treat acute respiratory distress syndrome by inhibiting the occurrence of inflammatory reaction, relieving bronchospasm and delaying lung tissue damage by exerting its effects of dispelling cold, dissolving cold and relieving cough so as to significantly improve the efficacy and reduce patient suffering.
文章编号：3201906029 中图分类号：R563.8 文献标志码：
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