Abstract:Objective To study the correlation of changes in myocardial enzymes and coagulation function level with trauma severity. Methods A total of 82 patients with multiple traumas from who were admitted to the hospital December 2017 to December 2018 were enrolled as study group. According to injury severity scoring (ISS) criteria, the study group were divided into mild trauma group (27 cases), moderate trauma group ( 29 cases) and severe trauma group (26 cases). The 28 healthy volunteers undergoing physical examination were enrolled as control group. The levels of myocardial enzymes [creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenase (LDH)] within 24h after admission and coagulation function levels [activated partial thromboplastin time (APTT), D-dimer (D-D) and platelet (PLT)] in study group were measured. The liver function [total bilirubin (TBil)] and renal function [serum creatinine (Scr), blood urea nitrogen (BUN))] after admission in each group were measured. The mortality was compared among all groups. Results The levels of CK, CK-MB, LDH, APTT, D-D, TBil, Scr and BUN in study group were significantly higher than the control group (P＜0.05). These indexes were significantly positively correlated with trauma severity (P＜0.05). PLT level of study group was lower than control group (P＜0.05), negatively correlated with trauma severity (P＜0.05). The mortality of severe trauma group was significantly higher than mild trauma group and moderate trauma group (P＜0.05). Conclusion The levels changes of myocardial enzymes and coagulation function could well reflect trauma severity. There was certain reference value for guiding clinical treatment.