Abstract:Objective To study the prognosis and related factors of rt-PA intravenous thrombolysis in patients with acute anterior circulation infarction combined with moderate to severe leukoaraiosis. Methods A retrospective analysis were made of 88 patients with acute anterior circulation infarction treated in target hospital from January 2015 to June 2018. According to the different treatment methods, all patients were divided into study group and control group. 48 patients in the study group were treated with rt-PA thrombolysis. 36 patients in the control group were not treated with thrombolysis. The limb motor function, nerve function, leukoaraiosis, infarct size and prognosis were observed and compared between these two groups. The patients'leukoaraiosis and infarct size were also studied. Results The baseline NIHSS score, 24h NIHSS score and 7d NIHSS score of the study group were significantly higher than the control group. There were no significant difference in admission FMS score between these two groups. The 90-day FMS score of the study group were significantly lower than the control group. Logistic regression analysis showed that moderate to severe leukoaraiosis (OR=4.565 2, 95% CI 1.200 1,67.725 1, P=0.032 7) was a risk factor for 90-day prognosis in patients with intravenous thrombolysis. Conclusion The incidence of hemorrhagic transformation in patients with acute anterior circulation infarction combined with moderate to severe leukoaraiosis was increased after rt-PA intravenous thrombolysis, moderate to severe leukoaraiosis might be an independent prognostic factor.