Abstract:Objective To study the relationship between ACR detection and renal function impairment in elderly patients with diabetes mellitus and hypertension. Methods 118 cases eligible patients treated in target hospital from June 2017 to June 2018 were selected as the subjects of this study and divided into hypertension group, diabetes group and hypertension combined with diabetes group according to their basic disease types. 50 healthy people in target hospital were selected as the control group. The levels of serum creatinine, urea nitrogen , uric acid, UmAlb and ACR were compared and analyzed. Results The positive rates of UA, UmAlb and ACR in hypertensive group, diabetic group and hypertensive + diabetic group were significantly higher than control group (P＜0.05). There was significant difference in ACR positive rate between different grades of hypertension subgroups (P＜0.05). There was no significant difference between grade 2 and grade 1 and grade 3 (P＞0.05). There was significant difference between grade 3 and grade 1 ACR positive rate (P＜0.05). There was no significant difference in ACR positive rate between different course subgroups of hypertension and diabetes mellitus (P＞0.05). Conclusion Hypertension, hypertension and diabetes often accelerate the occurrence and development of kidney damage. ACR had great significance in the diagnosis of early renal damage in hypertension and diabetes mellitus, and could be used as a sensitive index in the diagnosis of early renal damage in hypertension and diabetes mellitus.