Abstract:OBJECTIVE To investigate the effect of ERCP on the health education of WeChat platform in children with chronic pancreatitis. METHODS From February 2016 to February 2018, 112 children with chronic pancreatitis who underwent ERCP were selected in the target center. 56 children who had completed ERCP treatment were selected as the control group, and they would receive ERCP again later. The children who underwent surgery were included in the experimental group in a matched group, and the children in the control group and their families were given regular health education guidance. The children and their families in the experimental group were given the WeChat platform health education on the basis of routine knowledge, and the two groups were intervened. Height, weight, nutritional status, and recurrence rate of chronic pancreatitis after implementation were compared. RESULTS After the intervention, the height and weight of the children in the experimental group were higher than the control group (P<0.05). The serum albumin, serum prealbumin and serum transferrin levels in the experimental group were higher than the control(P<0.05); the recurrence rate of chronic pancreatitis in the experimental group was 3.57%, which was significantly lower than 14.29% in the control group (P=0.047). CONCLUSION WeChat platform health education in children with chronic pancreatitis after ERCP could improve the nutritional absorption level of children, promote their growth and development, and reduce the recurrence rate of chronic pancreatitis in children. It had good clinical effect, which was worthy of carrying out the application.