Abstract:OBJECTIVE To explore the quadruple therapy in combination with hydrotalcite treatment of patients with colorectal cancer complicated by helicobacter pylori (HP) infection and the effect of type of serum Ⅰ before collagen peptide the original ammonia, the influence of the stomach (17 level). METHODS From January 2016 to January 2018, 93 patients with colorectal cancer and helicobacter pylori infection were selected as study subjects, and divided into 41 patients in the control group and 52 patients in the observation group according to different treatment methods. The control group was treated with quadruple therapy, while the observation group was treated with magnesium aluminum carbonate on the basis of the control group. RESULTS The HP clearance rate of the observation group was significantly higher than the control group at 4, 8 and 14 days after treatment (P＜0.05). There was no significant difference in serum interleukin-6 (il-6) and c-reactive protein (CPR) levels between the control group and the observation group before treatment(P＞0.05). After treatment, serum il-6 and CPR levels in the observation group were significantly lower than those in the control group, with statistically significant differences (P＜0.05), and the decrease in the observation group was greater than that in the control group(P＜0.05). CONCLUSION magnesium aluminum carbonate combined with quadruple therapy could effectively improve HP clearance rate, reduce serum inflammatory factor level, reduce serum g-17 level and improve prognosis. It also improved PINP levels.