Abstract:OBJECTIVE To study the treatment and survival status of all patients found and managed in Luoyang from 1995 to 2018, and to explore the relevant influencing factors of treatment and survival. METHODS The data of 1532 HIV-infected persons confirmed and managed in Luoyang from 1995 to 2018 were collected, and the mortality rate was calculated. The relationship between risk factors and survival time were analyzed by COX proportional hazard regression model. The survival curve was drawn by Kaplan-Meier and the influencing factors of antiviral treatment were analyzed by Logistic regression model. RESULTS A total of 1 532 HIV-infected patients were followed up for 65 160 months. 168 of them died during the follow-up period. The mortality rate was 3.09/100 person-years. 1 295 cases(85%) received antiviral treatment. The mortality rate of patients receiving antiviral treatment was 1.74/100 person-years. The mortality rate of patients not receiving antiviral treatment was 18.49/100 person-years.Without antiviral treatment(ART), the first CD4 test was less than 200/uL, which significantly increased the risk of death of HIV-infected persons. It was easier to receive ART in urban follow-up, active detection, and the first CD4 test results less than 200/uL. CONCLUSION It showed that the mortality rate of HIV-infected people in Luoyang was still higher than Beijing and Shanghai. Early detection and ART could significantly increase the survival time. It should further strengthen publicity, expand the coverage of detection, shorten the time from primary screening to confirmation, simplify the process from confirmation to medication, promote “one-stop service” and maximize the treatment rate and follow-up rate.