Abstract:OBJECTIVE To investigate the effects of residual symptoms on functional impairment in patients with remission depression. METHODS 62 patients with depression admitted to the outpatient department of target hospital from January 2017 to December 2018 were selected, and all patients turned clinical remission after acute stage treatment. According to the Sheehan Disability Scale(SDS), the patients were divided into the normal functional group (n=40) and the abnormal functional group (n=22), and the residual symptoms and other related indicators of these two groups were compared, the correlation between residual symptoms and functional injury were analyzed. The effects of residual symptoms on functional injury were analyzed by multiple Logistics regression. RESULTS Sleep disorders were positively correlated with SDS score, work/learning function, and SDS score and each dimension were positively correlated with mental activity changes, depression/sadness and other residual symptoms (P<0.05). Compared with the normal functional group, the first onset of depression, the comorbidity of somatic diseases, the degree of somatic symptoms and the proportion of residual symptoms were significantly increased in the abnormal functional group, and the duration of medication was significantly shortened (P<0.05). Multiple Logistic regression showed that degree of somatic symptoms and residual symptoms were independent risk factors for functional impairment in patients with remission depression, while the onset of primary depression was a protective factor(P<0.05). CONCLUSION Patients with remission depression might suffer functional impairment of varying degrees, which was closely related to residual symptoms such as sleep disorders, changes in mental activity, depression/sadness. Residual symptoms were the influencing factors of functional impairment.