Abstract:OBJECTIVE To explore the value of extra-hospital following-up nursing on young and middle-aged patients with peritoneal dialysis. METHODS 80 young and middle-aged patients with peritoneal dialysis from January to December 2016 in target hospital were randomly divided into the observation group and the control group, 40 cases in each group. During the extra-hospital peritoneal dialysis period, the control group only received routine nursing, while the observation group was given following-up nursing management according to Orem theory. The quality of life was assessed by the KDQOL-36 questionnaire, the self-efficacy was assessed by the general self-efficacy scale (GSES), and the risk of malnutrition was assessed by the malnutrition score (MIS); the level of hemoglobin (Hb), Albumin level (ALB) and body mass index (BMI) were used to assess the nutritional status of patients. RESULTS At discharge, the differences of the scores of KDQOL-36, GSES and MIS score, the level of Hb, ALB and BMI between these two groups were not statistically significant (P＞0.05). At 6 month after discharge, the scores of KDQOL-36 and GSES of the two groups were significantly higher, and the MIS score was significantly lower than those at the discharge (P＜0.05). With the prolongation of the treatment time, the above indexes of the control group had no obvious change, but were continuously improved in the observation group, and the differences between these two groups were statistically significant (P＜0.05). CONCLUSION Extra-hospital following-up nursing intervention could help to continuously improve the quality of life, self-efficacy and nutritional status of young and middle-aged patients with peritoneal dialysis.