Abstract:Objective To explore the application value of 3 different localization techniques of ultrasound, mammography and ductoscopy in nonpalpable breast lesions (NPBL). Methods The clinical data of 100 patients with NPBL admitted to the hospital from May 2016 to May 2019 were retrospectively analyzed. 56 patients underwent ultrasound body surface localization and resection, and 21 patients underwent mammography guidewire localization and resection, and 23 patients with nipple discharge were treated with ductoscopy guidewire localization and resection. According to the pathological results of the patients, the value of the three localization techniques in the diagnosis and treatment of NPBL was analyzed. Results In 56 patients with ultrasound body surface localization, lesions could be accurately located and removed after combined with methylene blue staining, and postoperative pathological examination confirmed the presence of lesions, including 20 malignant lesions and 36 benign lesions. And the pathological results were consistent with BIRADS classification. In 21 patients with mammography examination, calcified lesions were seen, and the lesions could be accurately removed after combined guidewire localization, and 4 cases of malignant lesions and 17 cases of benign lesions were confirmed. In 23 cases with ductoscopy, lesions were found in breast duct, and its coincidence rate of pathological diagnosis was 91.3%, and lesions were accurately located and removed after guidewire localization combined with methylene blue staining. Conclusion These localization techniques of ultrasound, mammography and ductoscopy had high application value in the localization and qualitation of NPBL patients. It could accurately locate and excise lesions and improve the diagnosis and treatment of NPBL level.