Abstract:OBJECTIVE To study the effect of specific immunotherapy (SIT) on the immune and pro-inflammatory factors in children with bronchial diseases. METHODS 103 children with bronchial diseases were randomly divided into two groups according to RCT. Group A was treated with SIT on the basis of symptomatic support treatment, and group B was treated with symptomatic support alone. SPSS21.0 Software was used to package the clinical indexes of the two groups and to compare the transformation of immune indexes and pro-inflammatory factors and the improvement of clinical symptoms between the two groups RESULTS (1) there was no significant difference in IgE,CD3+,CD4+,CD8+,CD4+/CD8+ and other immune indexes between group B and group B before intervention, and the two groups were better than those before treatment (P＜0.05). However, the above indexes in group A were significantly better than those in group B after treatment (P＜0.05). (2) There was no significant difference in IL-4, IL-8, TNF-αand IFN-γ between group A and group B before treatment (P＜0.05). After treatment, the above indexes in group A were significantly better than group B (P＜0.05), but the above indexes in group A were significantly better than group B after treatment (P＜0.05). (3) There was no significant difference in nocturnal symptom scores between group A and group B before treatment (P＞0.05). After treatment, the scores of symptoms in group B were better than those before treatment, and group A was significantly better than group B(P＜0.05). CONCLUSION SIT treatment in the clinical treatment of bronchial diseases in children had a good clinical application value to improve the immune function, inhibit the level of inflammation and improve its clinical symptoms, which had great effect.