Abstract:OBJECTIVE In order to provide evidence for further reducing perinatal mortality by analyzing perinatal death cas⁃ es in Haizhu in the past 5 years. METHODS To understand the main reason and relevant influencing factors of induced labor due to birth defects base on the study of perinatal death cases from 2014 to 2018. RESULTS From 2009 to 2015, the perinatal mortality showed a downward trend； However a weak upward trend was showed after the universal two-child policy was released. The proportion of birth defects increased from 25.00% to 47.30% year by year，and ma⁃ ternal disease fluctuated between 10.99% to 15.00%. Most of the cases (62%~72%) induced by birth defects in the past five years were migrant pregnant women；the proportion of with more than 5 times of antenatal examination increased from 13.2% to 62.90%（P=0.000），meanwhile，with abnormal by prenatal screening less than or equal to 24 weeks also increased from 7.90% to 34.30%（P=0.043）. CONCLUSION Strengthening management of high risk pregnancy，perfecting the seamless connection between prenatal screening and diagnosis, strictly controlling the birth defect cases into perina⁃ tal period were key measures to further reduce perinatal mortality and to improve the health of women and children.