Abstract:OBJECTIVE The aim is to investigate the clinical efficacy of the treatment (orally traditional Chinese medicine compound de⁃ coctions according to TCM constitution combined with cervical local application of drugs) on the patients with cervical high-risk HPV persistent infection. METHODS A total of 280 patients with persistent high-risk HPV infection were randomly divided into study group and control group, of them, Baofukang suppository and human recombinant interferon α-2b vaginal effervescent capsules were alternately given to the control group. On the basis of local application of drugs, the treatment of orally traditional Chinese medicine compound decoctions according to TCM constitution was added to the study group for a total of 3 menstrual cycles. The efficacy was evaluated in the fourth cycle. RESULTS The total effective rate of the treatment group and the control group were 80.71% and 45.71%, respectively. Among them, the effective rate of the treatment group and the control group were 80% and 50%, for the patients with the constitution of phlegm-dampness, respectively; 81.25% and 46.88% for the patients with the constitution of damp-heat quali⁃ ty, respectively; 80% and 50% for the patients with the constitution of qi-deficiency, respectively; 80% and 45% for the patients with the constitution of yang-deficiency, respectively; 80% and 40% for the patients with the constitution of yin-deficiency, respectively; 77.78% and 33.33% for the patients with the constitution of qi-stagnation, respectively; 88.89% and 33.33% for the patients with the constitution of blood-putum, respectively. The effective rate were compared by rank sum test, all P＜0.05, and the differences were statistically significant. CONCLUSION For patients with persistent high-risk HPV infection in the cervix, on the basis of local applica⁃ tion of drugs of cervix, orally traditional Chinese medicine compound decoctions according to TCM constitution could significantly im⁃ prove the therapeutic effect.