Abstract:OBJECTIVE To analyze the report data of adverse event following immunization (AEFI) in Gaoming district of Foshan from 2015 to 2018 and find out the main problems on immunization program and provide reference for relevant decision-making. METH⁃ ODS AEFI data from 2015 to 2018 were classified and analyzed by descriptive epidemiological analysis by using of Excel 2007 and SPSS 17.0.software. RESULTS There were 857 198 vaccinations in Gaoming District. 266 AEFI cases were reported in 2015-2018 with a total reported incidence of 31.0/100 000. The number of reported cases of AEFI in male was slightly more than that in female, 80.5% of them were the children with family, 10.5% of them were in kindergartens, 83.5% of them were in groups of 0 to 5 year-old , 10.5% of them were concentrated in 6-year-old group and 10.5% of them were adults accounted for 6.0%; 157 cases (59.0%) had lo⁃ cal reactions such as local swelling and local nodules, followed by 138 cases (51.9%) of fever; the top five vaccines relating to the in⁃ crease of the overall frequency of various AEFI were DPT vaccine (acellular), group A meningococcal vaccine, leprosy vaccine, JE vac⁃ cine (attenuated) and DPT vaccine (children), accounting for 20.6%, 10.0%, 8.3%, 8.0% and 7.2% of the total reported cases, respec⁃ tively. CONCLUSION The reported incidence of AEFI in Gaoming District from 2015 to 2018 was basically stable, and the AEFI mon⁃ itoring system is running well. It should continue to pay attention to the quality of vaccine, analyze the correlation between AEFI and vaccine in time, strengthen the safety management of vaccine, and do a good job in immunization program in future.