Abstract:OBJECTIVE To investigate the clinical effect of the combination of meridian injection with acupoint application on coronary heart disease and angina pectoris. METHODS A total of 100 patients who were treated in the Department of Cardiology of Shenyang Traditional Chinese Medicine Hospital from December 2018 to June 2019 were randomly divided into a control group and a treatment group. Patients in the control group received conventional western medicine basic treatment. The patients were instructed to have a low-salt, low-fat diet and receive 0.9% sodium chloride injection 50 mL/5% glucose injection 50 mL + nitroglycerin injection 10 mg 3～5 mL/h intravenous Injection and acupoint application based on western medicine treatment. On the basis of western medicine treatment in the control group, the treatment group chose acupoint application at noon 11: 00～13: 00) daily, once a day for 20 minutes each time. Patients in both groups were treated continuously for 20 days. Observe the TCM syndrome scores (main symptoms), Hcy, NO, hs-CRP and NF-kB levels and clinical effectiveness of the two groups of patients before and after treatment. RESULTS The TCM syndrome symptom scores, Hcy, NO, hs-CRP and NF-kB contents of the two groups of patients were improved compared with those before treatment, and the treatment group was significantly better than the control group after treatment, and the differences were statistically significant (P<0.05); After treatment, the total effective rate of the control group was 66%, and the total effective rate of the treatment group was 90%, the difference was statistically significant (P <0.05). CONCLUSION Based on western medicine treatment combined with meridian flow injection acupoint application for coronary heart disease angina pectoris can effectively inhibit inflammatory response, anti-platelet aggregation, delay the rate of thrombosis, improve symptoms such as chest tightness, chest pain, and improve clinical effectiveness.