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中文摘要: 目的 探究抗精神病药物对住院患者合并骨质疏松的调查研究。方法 按照既往是否服用过抗精神病药物，将所选
取的精神病患者分为未用药组（n=235）和用药组（n=845），通过分析两组患者骨密度、骨质疏松和血清生化指标的差异性来进
行探究。结果 未用药组患者骨密度为（0.31±0.01）g/cm2，显著优于用药组的（0.24±0.01）g/cm（2 P＜0.05）。未用药组患者共有
44例骨质疏松，59例骨质减少；用药组患者共有491例骨质疏松，160例骨质减少，未用药组患者患病率显著低于用药组（P＜ 0.05）。未用药组骨血清钙含量为（1.89±0.45）mmol/L、磷含量为（0.81±0.02）mmol/L，显著高于用药组（P＜0.05），催乳素为
（83.05±24.39）mIU/L，显著低于用药组（P＜0.05）。结论 在精神病患者中，骨质疏松的患者人数较多，其中服用药物的患者
患病率更高。
Abstract:OBJECTIVE To investigate the investigation of antipsychotic drugs on osteoporosis in hospitalized patients. METHODS The
selected patients were grouped according to whether they had taken antipsychotics before. The non-medicated group（n=235）and the
medicated group（n=845）were explored by analyzing the differences in bone density, osteoporosis, and serum biochemical parameters
of patients in the UN and ME groups. RESULTS Bone mineral density（0.31±0.01）g/cm2 in the UN group was significantly better than
that in the ME group（0.24±0.01）g/cm（2 P＜0.05）. There were 44 cases of osteoporosis and 59 cases of osteopenia in the UN group,
and 491 cases of osteoporosis and 160 cases of osteopenia in the ME group. The prevalence of the UN group was significantly lower
than that of the ME group（P＜0.05）. Bone serum calcium content（1.89±0.45）mmol/L and phosphorus content（0.81±0.02）mmol/Lin
the UN group were significantly higher than those in the ME group（P＜0.05）, and prolactin（83.05±24.39）mIU/L was significantly
higher than that in the ME group. The group was low（P＜0.05）. CONCLUSION Among patients with mental illness, there were more
patients with osteoporosis, and among them, the prevalence was higher in patients taking drugs
keywords: psychosis osteoporosis investigation and research
文章编号：3202005030 中图分类号：R964 文献标志码：
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